High-resolution 3D printing enables the fabrication of precise and detailed microparts with seamless surfaces without parting lines and tolerance specifications in the nanometer range.
Complex structures (with undercuts)
Large-scale (porous) structures
High-resolution 3D printing can be used to produce filigree structures with seeded or incorporated cells, mimicking the native microenvironment of the cell.
Using biocompatible material in combination with the precision of the UpNano printing process, NanoOne is able to print structures and surface textures mimicking microenvironments. For illustration purposes a cartilage cell was placed on the roof of a miniaturized model of Vienna's St. Stephen's cathedral. The printing system can also be equipped with a stage top incubation system, guaranteeing native cell environment throughout the printing process.
Regenerative medicine relies on the stimulus of patients’ own regeneration mechanisms, induced by a combination of compatible cells, stimulation factors and so-called scaffolds. The scaffold enables a higher cell density at the time of implant placement, mechanically supports the defect area during the healing process and enhances the possibility of tissue self-assembly.
Sterile microfluidic elements
Internal elements such as separators, channels or membranes can be fabricated directly within a commercially available or custom-made microfluidic chip. The fabrication of semipermeable membranes enables the simulation of native transport mechanisms in vitro. The permeability of the structure is dependent on the printing parameters and thus can be adjusted in accordance with the characteristics of the tissue under investigation.
D. Mandt et al., Fabrication of placental barrier structures within a microfluidic device utilizing two-photon polymerization, International Journal of Bioprinting, 4,2 (2018).
Der Standard: Wiener Forscher bauen Plazenta mit 3D-Drucker nach, derStandard.at, August 2018
Kapsch Award for best graduates from the University of Applied Sciences Technikum Vienna